李濤主任醫(yī)師
四川大學(xué)華西醫(yī)院精神心理科
擅長(zhǎng)領(lǐng)域:精神心理科常見(jiàn)疾病的診斷與治療。?
執(zhí)業(yè)經(jīng)歷: 李濤,女,博士,研究員,精神病學(xué)博士生導(dǎo)師。國(guó)家杰出青年科學(xué)基金獲得者。 1987畢業(yè)于華西醫(yī)科大學(xué),獲醫(yī)學(xué)學(xué)士學(xué)位,同年留華西醫(yī)科大學(xué)附一院工作,任住院醫(yī)師。1994年獲華西醫(yī)科大學(xué)精神科博士學(xué)位,畢業(yè)后任華西醫(yī)科大學(xué)附一院精神科主治醫(yī)師1995-1996年赴英國(guó)倫敦大學(xué)精神病研究所遺傳研究室作為訪問(wèn)學(xué)者開(kāi)展國(guó)際合作研究,1997年再次赴英國(guó)倫敦大學(xué)精神病研究所遺傳研究室進(jìn)行博士后研究工作,1998年至今任英國(guó)倫敦大學(xué)精神病研究所遺傳研究室講師。1998-2000年任四川大學(xué)華西醫(yī)院精神科副研究員,2000年晉升為研究員,現(xiàn)任四川大學(xué)華西醫(yī)院心理衛(wèi)生中心主任和精神醫(yī)學(xué)研究室主任、博士生導(dǎo)師,擁有臨床精神病學(xué)(中國(guó))和遺傳學(xué)(英國(guó))雙博士學(xué)位。多年來(lái)潛心致力于精神疾病的病因?qū)W研究,特別是在探索精神分裂癥的分子遺傳機(jī)制方面取得了一些重要的研究成果,如在國(guó)際上率先報(bào)導(dǎo)COMT基因與精神分裂癥的發(fā)病相關(guān)。近幾年來(lái)開(kāi)展了大量以精神分裂癥為代表的精神疾病遺傳生物表型和分子遺傳的研究工作,從大腦結(jié)構(gòu)、功能和生化代謝等角度全面探討高級(jí)認(rèn)知活動(dòng)的神經(jīng)生物學(xué)基礎(chǔ)及其與精神疾病的關(guān)系,系統(tǒng)分析基因與疾病及其生物遺傳標(biāo)記的關(guān)系。李濤教授作為項(xiàng)目負(fù)責(zé)人先后承擔(dān)了20多項(xiàng)國(guó)家級(jí)和國(guó)際科研項(xiàng)目,共發(fā)表SCI引用論文70余篇。先后于1997年獲中國(guó)衛(wèi)生部頒發(fā)的“吳階平醫(yī)學(xué)研究獎(jiǎng)和保羅.楊森藥學(xué)研究獎(jiǎng)精神病學(xué)專業(yè)三等獎(jiǎng)”、2001年獲中共中央組織部、人事部、中國(guó)科學(xué)技術(shù)協(xié)會(huì)聯(lián)合頒發(fā)的第七屆“中國(guó)杰出青年科學(xué)家獎(jiǎng)”、2002年獲國(guó)家自然基金委享有盛譽(yù)的“國(guó)家杰出青年科學(xué)基金”、2005年獲中華全國(guó)婦女聯(lián)合會(huì)、中國(guó)科學(xué)技術(shù)協(xié)會(huì)、中國(guó)聯(lián)合國(guó)教科文組織全國(guó)委員會(huì)、歐萊雅中國(guó)聯(lián)合頒發(fā)的第二屆“中國(guó)女青年科學(xué)家獎(jiǎng)”、 2006年入選四川省人民政府“四川省學(xué)術(shù)和技術(shù)帶頭人”、2008年獲教育部自然科學(xué)一等獎(jiǎng)(排名第一)、2008年獲教育部創(chuàng)新團(tuán)隊(duì)(帶頭人)及2009年獲教育部長(zhǎng)江學(xué)者特聘教授稱號(hào)。 【任職】 中國(guó)神經(jīng)科學(xué)學(xué)會(huì)精神病學(xué)臨床與基礎(chǔ)專委會(huì)常委,中華醫(yī)學(xué)會(huì)精神病學(xué)分會(huì)委員;中華醫(yī)學(xué)遺傳學(xué)雜志編委,四川大學(xué)學(xué)報(bào)(醫(yī)學(xué)版)編委 【研究方向】 精神疾病的生物學(xué)機(jī)制研究 現(xiàn)任職務(wù): 精神醫(yī)學(xué)實(shí)驗(yàn)室主任,心理衛(wèi)生中心主任 現(xiàn)任職稱: 主任醫(yī)師,博士生導(dǎo)師,研究員。 科研成果: 自1991年以來(lái),作為項(xiàng)目主要負(fù)責(zé)人或主要執(zhí)行人共參加國(guó)家自然科學(xué)基金資助課題10項(xiàng),國(guó)家教委博士點(diǎn)基金資助課題4項(xiàng),CMB資助課題2項(xiàng),衛(wèi)生部杰出人材基金資助課題1項(xiàng),973課題1項(xiàng)。2002年獲國(guó)家自然科學(xué)基金委杰出青年基金課題資。目前已在國(guó)內(nèi)外雜志上發(fā)表論文80多篇,其中SCI引用的論文50多篇。參編專業(yè)參考書章節(jié)四篇。 發(fā)表論文情況 一、在國(guó)際學(xué)術(shù)期刊上發(fā)表的論文 1. L Yang, Tao Li, C Wiese, L Lannfelt, P Sokoloff, CT Xu, Z Zeng, JC Schwartz, XH Liu, HW Moises, No Association between schizophrenia and homozygosity at the D3 dopamine receptor gene. Am J Med Genetic (Neuropsychiatric Genetics) 1993; 48:83 2. Tao Li, L Yang, C Wiese, CT Xu, Z Zeng, B Giros, MG Caron, HW Moises, XH Liu, No association between alleles or genotypes at the dopamine transporter gene and schizophrenia. Psychiatry Research 1994; 52:17 3. Hans W Moises, Liu Yang, Tao Li, Bent Havsteen, Rolf Fimmers, Max P. Baur, Xiehe Liu, Irving I Gottesman, Potential linkage disequilibrium between schizophrenia and locus D22S278 on the long arm of chromosome 22. Am J Med Genetic (Neuro-psychiatric Genetics) 1995; 60:465 4. Chromosome 22 Collaborative Linkage Group, A combined analysis of D22S278 marker alleles in affected sib-pairs: Support for a susceptibility locus for schizophrenia at chromosome 22q12. American Journal of Medical Genetics (Neuropsychiatric Genetics), 1996: 67:40-45. 5. Tao Li, H Vallada, R Bell, X Liu, T Xie, DA Collier, CNTF and psychiatric disorders. Nature Genetics, [Correspondence] 1996; 13:143. 6. DA Collier, MJ Arranz, P Sham, S Battersby, P Gill, KJ Aitchison, M Sodhi, Tao Li, B Smith, J Morton, RM Murry, D Smith, G Kirov (1996) The serotonin transporter is a potential susceptibility gene for bipolar affective disorder. Neuroreport, 1996; 7:1675. 7. Tao Li, PC Sham, HP Vallada, T Xie, X Tang, X Liu, DA Collier, (1996) Preferential transmission of the high activity allele of COMT in schizophrenia. Psychiatric Genetics, 1996; 6:131 8. DA Collier, G Stober, T Li, A Heils, M Catalano, D Di Bella, MJ Arranz, RM Murray, HP Vallada, D Bengel, CR Muller, GW Roberts, E Smeraldi, G Kirov, P Sham and KP Lesch, A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Molecular Psychiatry; 1996; 1: 453-460 9. Tao Li, Clive Holmer, Pak Sham, Joe Birkett, George Kirov, K Peter Lesch, John Powell, Simon Lovestone, David Collier, Allelic functional variation of serotonin transporter expression is a susceptibility factor for late onset disease. Neuroreport 1997; 8(3): 683-686 10. Tao Li, Homero Vallade, Davis Curtis, Maria Arranzc, Ke Xu, Guiqing Cai, Hong Deng, Jun Liu Robin Murray, Xiehe Liu and David Collier. Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and allelic association of the low activity allele with bipolar affective disorder. Phamacogenetics 1997; 7: 349-353 11. Tao Li, Ke Xu, Hong Deng, Guiqing Cai, Jun Liu, Xiehe Liu, Rongan Wang, Xiaoyong Xiang, Jinghua Zhao, Robin M Murray, Pak C Sham and David A Collier. Association analysis of the dopamine D4 gene exon III VNTR and heroin abuse in Chinese subjects. Molecular Psychiatry 1997; 2:413-416 12. David A Collier, Maria J Arranz, Tao Li, Dennis Mupita, Nigel Brown, Janet Treasure. Association between 5-HT2a gene promoter polymorphism and anorexia nervosa. Lancet 1997; 350:412. 13. Tao Li, Xiehe Liu, Ying Hu and Fuming Sheng. Segregation analysis on bipolar affective disorder. Arch of Shanghai Psychiatry 1997; (New)9: 1-2 (in Chinese) 14. H Kunugi, HP Vallada, PC Sham, F Hoda, MJ Arranz, T Li, S Nanko, RM Murray, P McGuffin, M Owen, M Gill, DA Collier. Catechol-O-methyltransferase polymorphisms and schizophrenia: a transmission disequilibrium study in multiply affected families. Psychiatric Genetics 1997; 7(3): 97-101 15. Tao Li, Homero P Vallada, Xiehe Liu, Tao Xie, Xiangdong Tang, Jinghua Zhao, Michael C O Donovan, Robin m Murray, Pak C Sham and David A Collier. Analysis of CAG/CTG repeat size in Chinese subjects with schizophrenia and bipolar affective disorder using the repeat expansion detection method. Biological Psychiatry 1998; 44(11): 1160-1165 16. Treasure, J., Collier, D A., Arranz, M J., Li, T., and Mupita, D., Selective serotonin reputake inhibitors in anorexia nervosa. Lancet 1998; 350: 1033-1034. 17. Tao Li, Maria J Arranz, Katherino J Aitchison, Catherine Bryant, Xiehe Liu, Robert W Kerwin, Robin M Murray, Pak Sham, David A Collier. Case-control, haplotype relative risk and transmission disequilibrium analysis of a dopamine D2 receptor functional promoter polymorphism in schizophrenia. Schizophrenia Research 1998; 32: 87-92 18. Li, T., Hu, X., Chandy, G.K., Fantion, E., Kalman, K., Gutman, G., Gargus, J.J., Freeman, B.F., Murray, R.M., Dawson, E., Liu, X., Bruinvels, A.T., Sham, P.C., and Collier, D.A., Transmission disequilibrium analysis of a triplet repeat within the hkCa3 gene using family trios with schizophrenia. Biochemical and Biophysical Research Communications. 1998; 251: 662-665 19. Maria J. Arranz, Tao Li, J. Munro, X. Liu, Robin Murray, David A Collier and R.W. Kerwin, Lack of association between a polymorphism in the promoter region of the dopamine–2 receptor gene and clozapine response. Pharmacogenetics 1998, 8: 481-484 20. He_L, Li_T, Melville_C, Liu_S, Feng_GY, Gu_NF, Fox_H, Shaw_D, Breen_G, Liu_XH, Sham_P, Brown_J, Collier_D, StClair_D. 102T/C polymorphism of serotonin receptor type 2A gene is not associated with schizophrenia in either Chinese or British Populations. American Journal of Medical Genetics, 1999, 88(1): 95-98 21. Gerome Breen, John Brown, David Collier, Sophia Maud, Helen Fox, Tao Li, Duncan Shaw and David St. Clair. The -141C Del/Ins polymorphism of the dopamine receptor 2 gene is associated with schizophrenia in a British population. Am J Med Genetics 1999; 88(4): 407-410 22. Sharon Marsh, Elaina S.R. Collie-Duguid, Tao Li, Xiehe Liu, and Howard L. Mcleod. Ethnic variation in the thymidylate synthase enhancer region polymorphism among Caucasian and Asian populations. Genomics 1999; 58: 310-312 23. Tao Li, Xiehe Liu, Pak C Sham, Katherine J Aitchison, Guiqing Cai, Maria J Arrianz, Hong Deng, Jun Liu, George Kirov, Robin M Murray, David A Collier. Association analysis between dopamine receptor genes and bipolar affective disorder. Psychiatry Research 1999; 86: 193-201 24. G Green, P Sham, T Li, D Shaw, D A Collier and D St Clair. Accuracy and sensitivity of DNA pooling with microsatellite repeats using capillary electrophoresis. Molecular and Cellular Probes 1999; 13: 359-365 25. T Li, G. Breen, J. Brown, R. M. Murray, D.J. Shaw, P.C. Sham, D. St Clair and D.A. Collier. No evidence of linkage disequilibrium between a CAG repeat in the SCA1 gene and schizophrenia in Caucasian and Chinese schizophrenia subjects. Psychiatric Genetics 1999; 9(3): 123-127 26. Collie-Duguid ESR, Pritchard S C, Poerie R H, Sludden J, Collier D A, Li T, McLeod H L. The frequency and distribution of thiopurine methyltransferase alleles in Caucasian and Asian population. Pharmacogenetics 1999; 9(1): 37-42 27. A.J. Makoff, J.M. Graham, M.J. Arranz, J. Forsyth, T.Li, K.J. Aitchison, S.Shaikh and R. A. Grunewald. Association study of dopamine receptor gene polymoprhisms with drug-induced hallucinations in patients with idiopathic Parkinson’s disease. Pharmacogenetics 2000; 10: 43-48 28. Tao Li, Xiehe Liu, Zuo-Hong Zhu, Jinghua Zhao, Xun Hu, David M Ball, Pak C Sham and David A Collier. No association between (AAT)n repeats in the cannabinoid receptor gene (CNR1) and heroin abuse in a Chinese population. Molecular Psychiatry 2000; 5(2): 128-130 29. Tao Li, David Ball, Jinghua Zhao, Robin M Murray, Xiehe Liu, Pak C Sham, and David A Collier. Family-based linkage disequilibrium mapping using SNP marker haplotypes: application to a potential locus for schizophrenia at chromosome 22q11. Molecular Psychiatry 2000; 5: 77-84 30. Tao Li, Xiehe Liu, Zhu Zuo Hong, Jing Hua Zhao, Xun Hu, Pak C Sham and David A Collier. Association analysis of polymorphisms in the mu opioid gene and heroin abuse in the Chinese subjects. Addiction Biology 2000; 5: 181-186 31. Tao Li, Zuo-Hong Zhu, Xiehe Liu, jinghua Zhao, Pak C Sham and David A Collier. Association analysis of polymorphisms in the DRD4 gene and heroin abuse in the Chinese subjects. Am J Med Genetics 2000; 96:616-621 32. Li, T, Underhill, J, Liu XH, Sham PC, Donaldson, P, Murray RM, Wright, P and Collier DA. Transmission disequilibrium analysis of HLA class ii DRB1, DQA1, DQB1 and DPB1 POLYMORPHISMS IN schizophrenia using FAMILY trios FROM a HAN Chinese population. Schizophrenia Research 2001; 49(1-2): 73-78 33. Guiqing Cai, Tao Li, Hong Deng, Jinghua Zhao, Xun Hu, Robin Murray, Xiehe Liu, Pak Sham and David Collier. Affected sibling pair linkage analysis of qualitative and quantitative traits for schizophrenia on chromosome 22 in a Chinese population. Am J Med Genetics. 2001; 105 (4): 321-327 34. Margaret-Mary Ameyaw , Fernando Regateiro, Tao Li, Xiehe Liu , Mohammed Tariq, Abeer Mobarek, Nadia Thornton, Gbolahan O. Folayan, Jessie Githang'a , Anne Indalo, David Ofori-Adjei, David A. Price-Evans and Howard L. McLeod MDR1 pharmacogenetics: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity. Pharmacogenetics 2001, 11:217-221 35. Ralf M. Frieboes , Hans W. Moises, Wagner F. Gattaz , Liu Yang, Tao Li, Xiehe Liu, Peter Vetter, Fabio Macciardi, Hai G. Hwu, Fritz Henn. Lack of association between schizophrenia and the phospholipase-A2 genes cPLA2 and sPLA2. American Journal of Medical Genetics (Neuropsychiatric Genetics) 2001, 105(3): 246-249 36. Tao Li, Xiehe Liu, Jinghua Zhao, Xun Hu, David M Ball, El-Wui Loh, Pak C Sham and David A Collier. Allelic association analysis of the 2 receptors, and the serotonin transporter?dopamine D2, D3, 5-HT2a and GABA genes with heroin abuse in Chinese subjects. American Journal of Medical Genetics (Neuropsychiatric Genetics) 2002,114: 329-335. 37. Peng R, Gou Y, Yuan Q, Li T, Latsoudis H, Yuan G, Luo D, Liu X, Collier DA. Mutation screening and association analysis of the parkin gene in Parkinson's disease patients from South-west china. Eur Neurol. 2003;49(2):85-9. 38. Shi J, Zhang S, Ma C, Liu X, Li T, Tang M, Han H, Guo Y, Zhao J, Zheng K, Kong X, Zhang K, Su Z, Zhao Z. Association between apolipoprotein CI HpaI polymorphism and sporadic Alzheimer’s disease in Chinese. Acta Neurol Scand, 2004, 109 (2): 140-145. 39. Shi J, Zhang S, Tang M, Liu X, Li T, Han H, Wang Y, Guo Y, Zhao J, Li H, Ma C. Possible association between Cys311Ser polymorphism of paraoxonase 2 gene and late-onset Alzheimer’s disease in Chinese. Brain Res Mol Brain Res, 2004, 120 (2): 201-204. 40. Shi J, Zhang S, Tang M, Liu X, Li T, Wang Y, Han H, Guo Y, Hao Y, Zheng K, Kong X, Su Z, Tong Y, Ma C. The 1239G/C polymorphism in exon 5 of BACE1 gene may be associated with sporadic Alzheimer’s disease in Chinese Hans. Am J Med Genet, 2004, 124B: 54-57. 41. Yi Huang, Tao Li, Yun Wang, Jawaid Ansar, Guo Lanting, Xiehe Liu, Jing Hua Zhao, Xun Hu, Pak C Sham and David Collier. Linkage disequilibrium analysis of polymorphisms in the gene for Myelin Oligodendrocyte Glycoprotein in Tourette Syndrome patients from a Chinese Sample. American Journal of Medical Genetics (Neuropsychiatric Genetics). 2004, 124(1):76-80 42. Tao Li, Chiken Chen, Xun Hu, David Ball, Shih-Ku Lin, Wai Chen1, Pak C Sham, El-Wui Loh, Robin M. Murray, David A Collier. Association study between DRD4 and COMT genes and Methamphetamine Abuse in a Chinese Population. American Journal of Medical Genetics (Neuropsychiatric Genetics). 2004, 129B(1):120-4 43. Tao Li, Xiaohong Ma, Pak Sham, Xueli Sun, Xun Hu, Qiang Wang, Huaqing Meng, Wei Deng, Xiehe Liu, Robin Murray and David A Collier. Evidence for association between novel polymorphisms in the PRODH gene and schizophrenia in a Chinese population. American Journal of Medical Genetics (Neuropsychiatric Genetics). 2004 129B(1):13-5 44. T Li, H Stefansson, E Gudfinnsson, G Cai, X Liu, RM Murray, V Steinthorsdottir, D Januel, VG Gudnadottir, H Petursson, A Ingason, JR Gulcher, K Stefansson and DA Collier. Identification of a novel neuregulin 1 at-risk haplotype in Han schizophrenia Chinese patients, but no association with the Icelandic/Scottish risk haplotype. Molecular Psychiatry. 2004, 9(7): 698-704 45. Yu L, Li T, Robertson Z, Dean J, Gu NF, Feng GY, Yates P, Sinclair M, Crombie C, Collier DA, Walker N, He L, St Clair D. No association between polymorphisms of methylenetetrahydrofolate reductase gene and schizophrenia in both Chinese and Scottish populations. Mol Psychiatry. 2004; 9:1063-5 46. Raymond C.K. Chan, Ronald Y.L. Chen, Eric Y.H. Chen, Tomy C.K. Hui, Eric F.C. Cheung, H.K. Cheung, Pak Sham, Tao Li, and David Collier. The differential clinical and neurocognitive profiles of COMT SNP rs165599 genotypes in schizophrenia. Journal of the International Neuropsychological Society. 2005; 11: 1–3. 47. Tao Li, Feng Zhang, Xiehe Liu, Xueli Sun, Pak C Sham, Caroline Crombie, Xiaohong Ma, Qiang Wang Huaqing Meng, Wei Deng, Phil Yates, Xun Hu, Nicholas Walker, Robin M Murray, David A Collier and David St Clair. Identifying potential risk haplotypes for schizophrenia at DTNBP1 locus in Han Chinese and Scottish populations. Molecular Psychiatry. 2005;10: 1037-1044 48. Zhang F, St Clair D, Liu X, Sun X, Sham PC, Crombie C, Ma X, Wang Q, Meng H, Deng W, Yates P, Hu X, Walker N, Murray RM, Collier DA, Li T. Association analysis of the RGS4 gene in Han Chinese and Scottish populations with schizophrenia. Genes Brain Behav. 2005; 4(7):444-8. 49. Michael E. Talkowski, Howard Seltman, Anne S. Bassett, Linda M. Brzustowicz, Xiangning Chen, Kodavali V. Chowdari, David A. Collier, Quirino Cordeiro, Aiden P. Corvin, Smita N. Deshpande, Michael F. Egan, Michael Gill, Kenneth S. Kendler5, George Kirov, Leonard L. Heston, Pat Levitt, David A. Lewis, Tao Li, Karoly Mirnics, Derek W. Morris, Nadine Norton, Michael C. O’Donovan, Michael J. Owen, Christian Richard, Prachi Semwal, Janet L. Sobell1, David St Clair1, Richard E. Straub, Thelma B.K., Homero Vallada, Daniel R. Weinberger, Nigel M. Williams, Joel Wood, Feng Zhang, Bernie Devlin, and Vishwajit L. Nimgaonkar. Evaluation of a susceptibility gene for schizophrenia: genotype based metaanalysis of RGS4 polymorphisms from thirteen independent samples. Biological Psychiatry. 2006 Accepted for publication. 50. Prata DP, Breen G, Munro J, Sinclair M, Osborne S, Li T, Kerwin R, St Clair D, Collier DA. Bipolar 1 disorder is not associated with the RGS4, PRODH, COMT and GRK3 genes. Psychiatr Genet. 2006 Dec;16(6):229-30. 51. Breen G, Prata D, Osborne S, Munro J, Sinclair M, Li T, Staddon S, Dempster D, Sainz R, Arroyo B, Kerwin RW, St Clair D, Collier D. Association of the dysbindin gene with bipolar affective disorder. Am J Psychiatry. 2006 Sep;163(9):1636-8. 52. Xiaohong Ma, Qiang Wang, Pak C Sham, Xiehe Liu, Sophia Rabe-Hesketh, Xueli Sun, Junmei Hu, Huaqing Meng, Wai Chen, Eric YH Chen, Wei Deng, Raymond CK Chan, Robin M Murray, David A Collier and Tao Li. Neurocognitive deficits in first-episode schizophrenic patients and their first-degree relatives. American Journal of Medical Genetics (Neuropsychiatric Genetics). 2006 Accepted for publication. 53. Qiang Wang, Raymond Chan, Jinhua Sun, Jing Yao, Wei Deng, Xueli Sun, Xiehe Liu, Pak C Sham, Xiaohong Ma, Huaqing Meng, Robin M Murray, David A Collier and Tao Li. Reaction time of the Continuous Performance Test is an endophenotypic marker for schizophrenia: A study of first-episode neuroleptic-na?ve schizophrenia, their non-psychotic first-degree relatives and healthy population controls. Schizophrenia Research 2006 (in Press) 二、在國(guó)內(nèi)學(xué)術(shù)期刊上發(fā)表的論文 1. 李濤, 劉協(xié)和, 胡應(yīng), 沈福民: 雙相情感性障礙的分離分析 上海精神醫(yī)學(xué) 1997; 9(1):1-2 2. 李濤, 劉協(xié)和, 胡 應(yīng): 多巴胺轉(zhuǎn)運(yùn)體基因與雙相情感障礙 中華醫(yī)學(xué)遺傳學(xué)雜志 1996;13(5):273-277 3. 李濤, 劉協(xié)和: 雙相情感障礙家系調(diào)查報(bào)告 中華精神科雜志 1996; 29(3):140/143 4. 李濤, 劉協(xié)和, 胡 應(yīng)等: 遺傳和教育撫養(yǎng)因素在雙相情感障礙發(fā)病中的作用 上海精神醫(yī)學(xué) 1995; 新 7(3):176-178 5. 張嵐,劉協(xié)和,李濤,等。強(qiáng)迫癥藥物療效與六個(gè)功能基因的分子藥理遺傳學(xué)研究。中華醫(yī)學(xué)遺傳學(xué)雜志。2004年,21(5):479-481 6. 張嵐,劉協(xié)和,李濤,等。不同發(fā)病年齡強(qiáng)迫癥患者6種功能基因的分子遺傳學(xué)研究。中華精神科雜志。2004年,37(4):198-201 7. 王強(qiáng),孫學(xué)禮,李濤,等。首發(fā)精神分裂癥患者及其親屬的P300與兒茶酚氧位甲基轉(zhuǎn)移酶基因的相關(guān)性研究,中華精神科雜志,2004;37(2):123。 8. 馬小紅,王強(qiáng),孫學(xué)禮,李濤等,首發(fā)精神分裂癥神經(jīng)認(rèn)知功能的遺傳學(xué)分析。中華精神科雜志,2004;37(3):140-144。 9. 馬小紅,王英成,王強(qiáng),李濤等,首發(fā)精神分裂癥臨床表現(xiàn)與22號(hào)染色體上可能候選基因的關(guān)聯(lián)分析。中華精神科雜志,2004;37(3):145-148。 10. 馬小紅、王英成、李濤、黃 頤、劉協(xié)和、吳 斌、師建國(guó):不同年齡雙相情感性精神障礙患者與多巴胺D2、兒茶酚氧位甲基轉(zhuǎn)移酶基因多態(tài)性的關(guān)聯(lián)分析 中華精神科雜志 2003;36(1):21-24 11. 馬小紅、周 琴、李濤、王英成、黃 頤、孫學(xué)禮、劉協(xié)和、師建國(guó)、吳 斌:雙相情感障礙與DRD3、DRD2和COMT基因多態(tài)性的關(guān)聯(lián)分析. 中國(guó)神經(jīng)精神疾病雜志. 2003;29(2):84-87 12. 曹莉萍、李濤、劉協(xié)和:海洛因依賴與多巴胺D2受體基因的關(guān)聯(lián)分析 中華精神科雜志 2003; 36(1):31-33 13. 曹莉萍、李濤、劉協(xié)和:海洛因依賴與兒茶酚胺氧位甲基轉(zhuǎn)移酶基因的關(guān)聯(lián)研究中華醫(yī)學(xué)遺傳學(xué)雜志 2003;20(2):127-130 14. 黃 頤、劉協(xié)和、許 珂、李曉帆、李濤:精神分裂癥患者細(xì)胞色素P450 2D6酶基因多態(tài)性與利培酮治療效應(yīng)的關(guān)系 中華精神科雜志 2002;35(2):103-106 15. 曹莉萍、李濤、劉協(xié)和:海洛因依賴與多巴胺D4受體基因的關(guān)聯(lián)分析 中國(guó)神經(jīng)精神疾病雜志 2002; 28(1):60 16. 黃 頤、劉協(xié)和、李濤等:多巴胺D4受體第3外顯子48bp 可變重復(fù)序列多態(tài)性與抽動(dòng)障礙的傳遞不平衡檢測(cè) 中華醫(yī)學(xué)遺傳學(xué)雜志 2001;19(2):100-103 17. 蔡貴慶、伍新堯、李濤、David A. Collier、劉協(xié)和、馮炳建、鄧紅、童大躍、 李建金、區(qū)敬華:家族性精神分裂癥的定量性狀與1號(hào)染色體的連鎖分析 中華醫(yī)學(xué)遺傳學(xué)雜志 2002;19(4):281-284 18. 蔡貴慶、伍新堯、李濤、David A. Collier、劉協(xié)和、馮炳建、鄧 紅、童大躍、李建金、區(qū)敬華:中國(guó)人群中家族性精神分裂癥與1號(hào)染色體的連鎖分析 中華醫(yī)學(xué)遺傳學(xué)雜志 2002; 19(6):491-494 19. 曹莉萍、李濤、許 珂、劉協(xié)和:海洛因依賴與兒茶酚胺氧位甲基轉(zhuǎn)移酶基因-287 A/G 多態(tài)性的關(guān)聯(lián)研究 中華醫(yī)學(xué)遺傳學(xué)雜志 2002; 19(6):499-501 20. 彭 蓉、茍嬰如、袁 強(qiáng)、李濤、袁光固、羅德儒、劉協(xié)和、David A. Collier: 多巴胺D2受體基因啟動(dòng)子多態(tài)性與帕金森病的關(guān)聯(lián)研究 中華醫(yī)學(xué)遺傳學(xué)雜志 2002; 19(6):524-525 21. 黃 頤、劉協(xié)和、李濤等:5-HT 102T/C 多態(tài)性與Tourette綜合征的病例對(duì)照及核心家系關(guān)聯(lián)分析 中華醫(yī)學(xué)遺傳學(xué)雜志 2001; 18(1):11-13 22. 曹莉萍、李濤、許珂、劉協(xié)和:自殺未遂與5-羥色胺2A受體基因的關(guān)聯(lián)分析. 中華醫(yī)學(xué)遺傳學(xué)雜志 2001;18(3):195-197 23. 蔡貴慶、鄧紅、李濤、劉協(xié)和:精神分裂癥受累同胞臨床特征的研究 臨床精神醫(yī)學(xué)雜志 2001;11(4):232-235 24. 蔡貴慶、李濤、鄧 紅、吳梅筠、劉協(xié)和、David A. Collier: 中國(guó)人群中精神分裂癥與22號(hào)染色體的連鎖不平衡研究 中華醫(yī)學(xué)遺傳學(xué)雜志 2001;18(5):335-337 25. 曹莉萍、李濤、許珂、劉協(xié)和:自殺未遂與5-羥色胺2A受體基因的關(guān)聯(lián)分析. 中華醫(yī)學(xué)遺傳學(xué)雜志 2001;18(3):195-197 26. 蔡貴慶、鄧紅、李濤、劉協(xié)和:精神分裂癥受累同胞臨床特征的研究 臨床精神醫(yī)學(xué)雜志 2001;11(4):232/235 27. 唐牟尼,李濤,劉協(xié)和,韓海英,唐銘民,Collier DA: 載脂蛋白E、5-羥色胺轉(zhuǎn)運(yùn)體基因多態(tài)性與阿爾茨海默病的關(guān)聯(lián)分析 中華精神科雜志 2000;33(3):145-148 三.參編章節(jié) 1. 李 濤,精神疾病的遺傳。楊徳森主編: 精神病學(xué)基礎(chǔ)。湖南科技出版社1994 2. 李 濤,情感障礙的遺傳研究。姚芳傳主編:情感性精神障礙。湖南科技出版社1998 3. 趙京華,李濤,Pak Chung Sham。連鎖分析和關(guān)聯(lián)分析。賀林主編:解碼生命:人類基因組計(jì)劃和后基因組計(jì)劃??茖W(xué)出版社2000 4. David A Collier, Tao Li. Genetic epidemiology 2: Molecular Genetics. IN: Prince et al. ed. Practical Psychiatric Epidemiology. Oxford University Press. 2003 詳細(xì)介紹
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